Jacek Bielawski Selected Research

Ceramides

3/2017	Increased Plasma Levels of Select Deoxy-ceramide and Ceramide Species are Associated with Increased Odds of Diabetic Neuropathy in Type 1 Diabetes: A Pilot Study.
1/2017	Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study.
1/2017	Sphingomyelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes.
1/2017	Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.
12/2016	Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells.
11/2016	Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.
6/2016	Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway.
5/2016	Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency.
12/2015	Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3.
9/2015	Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression.

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Jacek Bielawski Research Topics

Disease

39	Neoplasms (Cancer) 12/2018 - 10/2004
13	Squamous Cell Carcinoma of Head and Neck 01/2019 - 10/2004
8	Breast Neoplasms (Breast Cancer) 01/2021 - 06/2004
8	Squamous Cell Carcinoma (Epidermoid Carcinoma) 11/2014 - 01/2011
7	Inflammation (Inflammations) 01/2018 - 07/2009
5	Carcinogenesis 01/2017 - 02/2006
4	Colonic Neoplasms (Colon Cancer) 01/2017 - 02/2006
4	Obesity 04/2014 - 09/2006
3	Lymphoma (Lymphomas) 09/2015 - 05/2008
3	Insulin Resistance 04/2014 - 05/2008
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/2013 - 04/2007
3	Neuroblastoma 05/2012 - 11/2003
3	Prostatic Neoplasms (Prostate Cancer) 03/2009 - 09/2007
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 11/2015
2	Dementia (Dementias) 05/2016 - 08/2014
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 05/2016 - 08/2014
2	Head and Neck Neoplasms (Head and Neck Cancer) 06/2015 - 09/2011
2	Neoplasm Metastasis (Metastasis) 01/2014 - 10/2007
2	Carcinoma (Carcinomatosis) 01/2014 - 10/2004
2	Lung Neoplasms (Lung Cancer) 08/2013 - 01/2013
2	Necrosis 01/2013 - 01/2006
2	Hypoxia (Hypoxemia) 09/2008 - 06/2008
2	Leukemia 06/2008 - 05/2008
2	Mitochondrial Diseases (Mitochondrial Disease) 08/2007 - 10/2004
1	Farber Lipogranulomatosis 12/2018
1	Relapsing-Remitting Multiple Sclerosis 01/2018
1	Demyelinating Diseases (Demyelinating Disease) 01/2018
1	Gliosis 01/2018
1	Diabetic Neuropathies (Diabetic Neuropathy) 03/2017
1	Type 2 Diabetes Mellitus (MODY) 03/2017
1	Polyneuropathies (Polyneuropathy) 03/2017
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2017
1	Acute Kidney Injury (Acute Renal Failure) 01/2017
1	Radiation Injuries (Radiation Sickness) 01/2017
1	Colorectal Neoplasms (Colorectal Cancer) 01/2017
1	Oligodendroglioma 11/2016
1	Fibrosis (Cirrhosis) 04/2016
1	Cardiomegaly (Heart Hypertrophy) 04/2016
1	Type A Niemann-Pick Disease 12/2015
1	Stomach Neoplasms (Stomach Cancer) 10/2015

Drug/Important Bio-Agent (IBA)

49	CeramidesIBA 03/2017 - 11/2003
29	SphingolipidsIBA 01/2021 - 09/2006
13	dihydroceramide desaturaseIBA 01/2017 - 06/2007
12	1-phenyl-3,3-dimethyltriazene (PDT)IBA 06/2016 - 05/2008
10	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2018 - 04/2007
8	sphingosine kinaseIBA 01/2017 - 02/2006
7	EnzymesIBA 12/2018 - 01/2006
7	Acid CeramidaseIBA 12/2018 - 09/2007
7	Proteins (Proteins, Gene)FDA Link 10/2015 - 02/2006
5	SphingosineIBA 01/2017 - 01/2006
5	SiliconesIBA 12/2013 - 01/2011
5	Small Interfering RNA (siRNA)IBA 07/2012 - 02/2006
4	Caspase 3 (Caspase-3)IBA 01/2017 - 11/2006
4	Photosensitizing Agents (Photosensitizers)IBA 05/2015 - 02/2010
4	silicon phthalocyanineIBA 05/2015 - 01/2013
4	Messenger RNA (mRNA)IBA 11/2014 - 02/2006
4	phthalocyanine Pc 4IBA 07/2012 - 01/2011
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 09/2011
3	Cisplatin (Platino)FDA LinkGeneric 01/2017 - 10/2015
3	SphingomyelinsIBA 01/2017 - 09/2008
3	AzoxymethaneIBA 01/2017 - 02/2006
3	Glucosylceramides (Glucocerebrosides)IBA 01/2017 - 04/2011
3	FenretinideIBA 06/2016 - 09/2010
3	safingol (sphinganine)IBA 10/2015 - 09/2010
3	Biological ProductsIBA 11/2014 - 10/2004
3	Gemcitabine FDA Link 01/2013 - 06/2006
2	LCL521IBA 12/2018 - 12/2016
2	Sphingosine-1-Phosphate ReceptorsIBA 01/2018 - 04/2016
2	Pharmaceutical PreparationsIBA 01/2018 - 01/2013
2	Fingolimod Hydrochloride (FTY720)FDA Link 01/2018 - 01/2013
2	ceramide glucosyltransferaseIBA 01/2017 - 10/2011
2	fumonisin B1IBA 01/2017 - 11/2014
2	thermozymocidin (myriocin)IBA 04/2016 - 12/2015
2	Imatinib Mesylate (Gleevec)FDA Link 10/2011 - 04/2007
2	LipidsIBA 11/2010 - 06/2008
2	Telomerase (Telomerase Reverse Transcriptase)IBA 10/2004 - 11/2003
1	Docetaxel (Taxotere)FDA Link 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	CuprizoneIBA 01/2018
1	2- (4- (5- (3,4- diethoxyphenyl)- 1,2,4- oxadiazol- 3- yl)- 2,3- dihydro- 1H- inden- 1- yl amino)ethanolIBA 01/2018
1	Amino Acids FDA Link 03/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	CarcinogensIBA 01/2017
1	CeramidasesIBA 12/2016
1	CytokinesIBA 11/2016
1	temoporfinIBA 06/2016
1	SEW2871IBA 04/2016
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2015
1	1-deoxysphingolipidIBA 11/2015
1	LyasesIBA 10/2015
1	GlycosphingolipidsIBA 10/2015
1	3- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amideIBA 09/2015
1	Eosine Yellowish-(YS) (Eosin)IBA 06/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2015
1	Hematoxylin (Haematoxylon)IBA 06/2015

Therapy/Procedure

8	Therapeutics 12/2018 - 01/2008
8	Photochemotherapy (Photodynamic Therapy) 06/2016 - 02/2010
6	Drug Therapy (Chemotherapy) 01/2020 - 09/2007
3	Chemoprevention 01/2017 - 02/2009
1	Immunotherapy 12/2016